|
|
Title: |
Vitamin-Dependent Multienzyme Complexes of 2-Oxo Acid Dehydrogenases |
| Sub-title: |
Structure, Function, Regulation & Medical Implications |
Search Result:
| By (author): |
Victoria Bunik |
| ISBN10-13: |
1536121665 : 9781536121667 |
| Format: |
Hardback |
| Size: |
230x155mm |
| Pages: |
160 |
| Weight: |
.430 Kg. |
| Published: |
Nova Science Publishers, Inc - July 2017 |
| List Price: |
185.99 Pounds Sterling |
| Availability: |
Temporarily Out of Stock, more expected soon
|
| Subjects: |
Biochemistry |
| This book summarises current data on the architecture, structure-function relationships, reaction mechanisms and active site coupling in multienzyme complexes of 2-oxo acid dehydrogenases. Special focus concerns the mechanisms of function and regulation of a multienzyme structure, additional to those inherent in its component enzymes. The overall physiological process of 2-oxo acid oxidative decarboxylation and the substrate specificity determinants are considered along with side reactions of regulatory significance, such as non-oxidative reactions, formation of reactive oxygen species (ROS) and complex-bound thiyl radicals. The significance of the chemical interplay between the complex-bound dihydrolipoate intermediate, thioredoxin or thioredoxin-like proteins, and peroxiredoxins for sensing metabolic state and adjusting the catalysis accordingly, is considered. Other mechanisms involved in the short- and long-term regulation of 2-oxo acid dehydrogenase complexes are summarized in view of their relevance to physiological functions. Metabolic regulation by natural effectors of 2-oxo acid dehydrogenase complexes and their synthetic analogues is considered. The medical implications of enzymological knowledge on the complexes are also presented. |
| Table of Contents: |
| Preface; Introduction; Principles of Self-Assembly of 2-Oxo Acid Dehydrogenase Complexes; Catalytic Mechanism of Physiological 2-Oxo Acid Dehydrogenase Reaction; Side Reactions Catalysed by 2-Oxo Acid Dehydrogenase Complexes; Functional Significance of Variable Component Stoichiometry of 2-Oxo Acid Dehydrogenase Complexes; Principles of Regulation of 2-Oxo Acid Dehydrogenase complexes; Medical Implications of 2-Oxo Acid Dehydrogenase Complexes; Conclusion; References; Index. |
|
|
Item added to 
.png "Click here for catalogues")
