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Title: |
Trends in Angiogenesis Research |
Search Result:
| Edited by: |
Roberta V Zubar |
| ISBN10-13: |
1594544522 : 9781594544521 |
| Illustrations: |
tables & charts |
| Format: |
Hardback |
| Size: |
180x260mm |
| Pages: |
254 |
| Weight: |
.785 Kg. |
| Published: |
Nova Science Publishers, Inc (US) - June 2005 |
| List Price: |
190.99 Pounds Sterling |
| Availability: |
In Stock
Qty Available: 1 |
| Subjects: |
Cardiovascular medicine |
| Angiogenesis -- the growth of new blood vessels -- is an important natural process occurring in the body, both for health and as related to disease. Angiogenesis occurs in the healthy body to help heal wounds and to help restore blood flow to tissues after injury or insult. In females, angiogenesis also occurs during the monthly reproductive cycle (to rebuild the uterus lining, to mature the egg during ovulation) and during pregnancy (to build the placenta, the circulation between mother and foetus). The healthy body controls angiogenesis through a series of "on" and "off" switches. The main "on" switches are known as angiogenesis-stimulating growth factors. The main "off switches" are known as angiogenesis inhibitors. When angiogenic growth factors are produced in excess of angiogenesis inhibitors the balance is tipped in favour of blood vessel growth. When inhibitors are present in excess of stimulators, angiogenesis is stopped. The normal, healthy body maintains a perfect balance of angiogenesis modulators. In general, angiogenesis is "turned off" by the production of more inhibitors than stimulators. Tumour angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. Tumour angiogenesis actually starts with cancerous tumour cells releasing molecules that send signals to surrounding normal host tissue. This signalling activates certain genes in the host tissue that, in turn, cause proteins to encourage growth of new blood vessels. This new book examines its angiogenesis within the context of theory and its applications to cancer treatment. |
| Table of Contents: |
| Preface; Proteolytic Fragments of Extracellular Matrix Components As Angiogenic Regulators; Studies of the Endothelial Cell-Specific Signal transduction Pathways. New Paradigm for the Development of Potent Anti-Angiogenic Therapies; Hormonal Effects on Endometrial Angiogenesis; Software Supported Quantification of Angiogenesis in an In Vitro Culture System. Examples of Applications in Studies of Basic Research, Biocompatibility and Drug Discovery; Estin, A Potent Angiogenesis Inhibitor Derived from Type XV Collagen; Endothelial Cell Adhesion Molecules, Inflammation and Atherosclerosis; The Effects of the Endothelins -- An Angiogenic Family of Molecules in Solid Cancers; Vascular Endothelial Growth Factor and Breast Cancer; Involvement of Erythropoietin in Angiogenesis of Normal and Malignant Tumors of Female Reproductive Organs; Index. |
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