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Title: |
Telomerase |
| Sub-title: |
Composition, Functions & Clinical Implications |
Search Result:
| Edited by: |
Aiden N Gagnon |
| ISBN10-13: |
1616689579 : 9781616689575 |
| Illustrations: |
tables, graphs, diagrams |
| Format: |
Hardback |
| Size: |
155x230mm |
| Pages: |
159 |
| Weight: |
.372 Kg. |
| Published: |
Nova Science Publishers, Inc (US) - March 2011 |
| List Price: |
84.99 Pounds Sterling |
| Availability: |
In Stock
Qty Available: 1 |
| Subjects: |
DNA & Genome |
| Telomerase is a ribonucleoprotein enzyme that catalyses the cellular synthesis of telomeric DNA during cellular division, resulting in maintenance of telomere length and increased proliferative potential. Several studies suggest that the telomerase may play an important role in the diagnosis and prognosis of cancer because its expression strongly correlates with the potential tumour progression. Ninety percent of human cancers on different organs have shown high telomerasa activity. This book reviews research in the field of telomerase including functions of telomerase independent of its interaction with telomeres on gene expression and chromatin structure; histone deacetylase inhibition as an anticancer telomerase-targeting strategy and others. |
| Table of Contents: |
| Preface; Telomerase Beyond Telomeres: New Roles for an Old Enzyme; Telomerase & Telomeric Proteins: A Life Beyond Telomeres; Histone Deacetylase Inhibition as an Anticancer Telomerase-Targeting Strategy; Telomerase Role in Pituitary Adenomas; Regulations of Telomerase Activity & WRN Gene Expression; Telomerase & Telomere Dynamics in Cancer: Clinical Application for Cancer Diagnosis; Index. |
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