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Title: |
Vimentin Concepts & Molecular Mechanisms |
Search Result:
| Edited by: |
Ramon Andrade de Mello |
| ISBN10-13: |
1624173594 : 9781624173592 |
| Format: |
Hardback |
| Size: |
260x180mm |
| Pages: |
196 |
| Weight: |
.548 Kg. |
| Published: |
Nova Science Publishers, Inc (US) - April 2013 |
| List Price: |
212.99 Pounds Sterling |
| Availability: |
Temporarily Out of Stock, more expected soon
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| Subjects: |
Proteins |
| Intermediate filaments (IFs) are among the main cytoskeleton components in most animal cells, being intermediate in diameter between microtubules and actin filaments. Vimentin is one of the large intermediate filaments (IFs) of eukaryotic cell's cytoskeleton, being the major protein in mesenchymal cells and it is frequently used as a developmental marker of cells and tissues. It may be overexpressed in several cancers, such as lung, breast, head and neck cancer, and sarcomas. Furthermore, it plays a main role in rheumatoid arthritis and Crohn's disease. Thus, this book will address main topics concerning promising therapeutic targets for intestinal fibrosis, vimentin's potential role in epithelial mesenchymal transition (EMT), the role of vimentin in rheumatoid arthritis, vimentin mechanisms and endothelial migration, and EMT and lung neoplasms. Also discussed are insights into the proteomics' field. Many reputed experts worldwide contributed to improvement of this book and it will give readers the state of art regarding vimentin and novel approaches. |
| Table of Contents: |
| Preface; Introduction to Vimentin & Novel Approaches; Vimentin during Development: Expression, Regulation & Functions; Vimentin-Positive, Profibrogenic Mesenchymal Cells in Intestine: Promising Therapeutic Targets for Intestinal Fibrosis; Intermediate Filament Vimentin & Potential Role in Epithelial Mesenchymal Transition (EMT); The Role of Vimentin in Rheumatoid Arthritis; Vimentin Mechanisms on Endothelial Migration; Vimentin Expression in Head & Neck Cancer; EMT Status in Lung Neoplasm; Vimentin & Proteomics; Index. |
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