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Title: |
Type I Interferon in Autoimmune Diseases & its Clinical Applications |
Search Result:
| Edited by: |
Yihong Yao |
| ISBN10-13: |
1624173799 : 9781624173790 |
| Format: |
Hardback |
| Size: |
260x180mm |
| Pages: |
349 |
| Weight: |
.738 Kg. |
| Published: |
Nova Science Publishers, Inc (US) - June 2013 |
| List Price: |
252.99 Pounds Sterling |
| Availability: |
In Stock
Qty Available: 1 |
| Subjects: |
Immunology |
| Auto-immune diseases such as systemic lupus erythematosus (SLE), Sjögren's syndrome, psoriasis, scleroderma (SSc) and myositis are heterogeneous disorders that result from interactions between genetic and environmental factors. Type I interferons (IFNs), especially IFN-α/β, have multiple biological functions including anti-viral and anti-bacterial properties, immuno-modulation, anti-proliferation, and intensive studies over decades have also revealed important roles in auto-immunity and cancer. Sustained Type I IFN elevation has been implicated in immune responses against self-antigens and tissue damage, which has led to the hypothesis that type I IFN might play a critical role in the pathogenesis of some auto-immune and inflammatory diseases. This book provides an overview of many key topics surrounding type I IFNs, beginning with detailed discussion of the type I IFN signalling pathway, the interplay between components that regulate this pathway, its involvement in auto-immunity, and a detailed review of the roles of type I IFNs in a series of well characterised inflammatory and auto-immune diseases. |
| Table of Contents: |
| Preface; Type I Interferon Signalling Pathway & its Regulation; Type I Interferons & Autoimmunity; Type I Interferons in Systemic Lupus Erythematosus; Type I Interferons in Sjögren’s Syndrome; Type I Interferons in Systemic Sclerosis; The Type I Interferon System in Rheumatoid Arthritis; Type I Interferons in Psoriasis; Type I Interferons in Dermatomyositis & Polymyositis; The Interferon System in MS: Towards a Personalized Medicine Approach for IFN-β Therapy; Developing Anti-Type I Interferon Therapy in Autoimmune Diseases & Personalized Medicine; Index. |
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